Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | LTK | P29376 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862990 | 1.00 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL857064 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8464117 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8464120 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL5465283 | 0.81 | NTRK1 (0.73) | CHEK1NTRK1KDRPRKD3ABL1 | |
| SCHEMBL6861663 | 0.81 | NTRK1 (0.73) | CHEK1NTRK1KDRPRKD3ABL1 | |
| SCHEMBL5465281 | 0.81 | NTRK1 (0.73) | CHEK1NTRK1KDRPRKD3ABL1 | |
| SCHEMBL8467707 | 0.80 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8467705 | 0.80 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL6288777 | 0.79 | CHEK1 (0.76) | CHEK1CHEK2CDK1SRCCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6797825-B2 | 1,3-DIHYDRO-2H-INDOL- 2-ONE DERIVATIVES | ABBOTT LABORATORIES | 2004-09-28 | — | — | US | disclosed |
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885CHEK2 93/4885CDK1 62/4885 |
| US-20030119839-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885CHEK2 93/4885CDK1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.