Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.60 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8467707 | 1.00 | CHEK1 (0.73) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8464117 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL857064 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8464120 | 0.85 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7550684 | 0.84 | CHEK1 (0.67) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7550675 | 0.84 | CHEK1 (0.67) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7553603 | 0.84 | CHEK1 (0.69) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7553386 | 0.84 | CHEK1 (0.69) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL6261047 | 0.84 | CHEK1 (0.69) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7553391 | 0.84 | CHEK1 (0.69) | CHEK1CHEK2CDK1SRCCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626963-B1 | VINYLENE-AZAINDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-06-09 | — | — | EP | claimed |