Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.64 |
| ▸ | TUBB | P07437 | 1/20 | 0.64 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.64 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.64 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.64 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.64 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.64 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.64 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.64 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.64 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.64 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.64 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.64 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.64 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.64 |
| ▸ | SGK1 | O00141 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | TEK | Q02763 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862997 | 1.00 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6671848 | 0.88 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6671843 | 0.88 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL8199248 | 0.82 | CHEK1 (0.70) | CHEK1CHEK2PDGFRBRETKDR | |
| SCHEMBL8199244 | 0.82 | CHEK1 (0.70) | CHEK1CHEK2PDGFRBRETKDR | |
| SCHEMBL8211131 | 0.81 | RET (0.73) | CHEK1CHEK2PDGFRBRETKDR | |
| SCHEMBL8211128 | 0.81 | RET (0.73) | CHEK1CHEK2PDGFRBRETKDR | |
| SCHEMBL6861577 | 0.80 | CHEK1 (0.69) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6860670 | 0.80 | CHEK1 (0.69) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6646612 | 0.80 | CHEK1 (0.69) | CHEK1CHEK2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | claimed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | claimed |
| US-6797825-B2 | 1,3-DIHYDRO-2H-INDOL- 2-ONE DERIVATIVES | ABBOTT LABORATORIES | 2004-09-28 | — | — | US | disclosed |
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | disclosed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885CHEK2 93/4885TUBB4A 1671/4885 |
| US-20030119839-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885CHEK2 93/4885TUBB4A 1671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.