Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.70 |
| ▸ | RET | P07949 | 6/20 | 0.67 |
| ▸ | KDR | P35968 | 8/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.61 |
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | FLT3 | P36888 | 3/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.61 |
| ▸ | FLT1 | P17948 | 2/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199244 | 1.00 | CHEK1 (0.70) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL8211131 | 0.87 | RET (0.73) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL8211128 | 0.87 | RET (0.73) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL6326741 | 0.84 | RET (0.63) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL6326747 | 0.84 | RET (0.63) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL5431032 | 0.83 | FGFR1 (0.77) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL5431036 | 0.83 | FGFR1 (0.77) | CHEK1KDRFGFR1PDGFRBEGFR | |
| SCHEMBL6863002 | 0.82 | CHEK1 (1.00) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL6862997 | 0.82 | CHEK1 (1.00) | CHEK1RETKDRFGFR1PDGFRB | |
| SCHEMBL8205880 | 0.81 | PDGFRB (0.72) | CHEK1KDRFGFR1PDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |