Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 10/20 | 0.65 |
| ▸ | NMT1 | P30419 | 10/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609719 | 0.86 | NMT2 (0.73) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6867241 | 0.84 | NMT2 (0.71) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL3609306 | 0.84 | NPC1 (0.76) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6868614 | 0.82 | NMT2 (0.71) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6871391 | 0.82 | NMT2 (0.71) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL10741778 | 0.80 | NPC1 (0.73) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL3607399 | 0.79 | KDM4E (0.76) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6874240 | 0.79 | NMT2 (1.00) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6869552 | 0.78 | NMT2 (1.00) | NMT2NMT1ADRB2ADRB1ADRB3 | |
| SCHEMBL6871813 | 0.78 | NMT2 (1.00) | NMT2NMT1ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149094-B1 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2004-04-21 | — | — | EP | disclosed |
| US-6376491-B1 | BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS | BASILEA PHARMACEUTICA AG (CH) | 2002-04-23 | — | — | US | disclosed |
| EP-1149094-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | Basilea Pharmaceutica AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000037464-A2 | 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS | BASILEA PHARMACEUTICA AG (CH) | 2000-06-29 | — | — | WO | disclosed |