Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.47 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12005815 | 1.00 | NAMPT (0.51) | NAMPTSIGMAR1RAB9ANPC1KMT2A | |
| SCHEMBL12005814 | 1.00 | NAMPT (0.51) | NAMPTSIGMAR1RAB9ANPC1KMT2A | |
| SCHEMBL6865017 | 0.89 | EPHX2 (0.45) | NAMPTSIGMAR1RAB9ANPC1KMT2A | |
| SCHEMBL12005197 | 0.89 | EPHX2 (0.45) | NAMPTSIGMAR1RAB9ANPC1KMT2A | |
| SCHEMBL12005199 | 0.89 | EPHX2 (0.45) | NAMPTSIGMAR1RAB9ANPC1KMT2A | |
| SCHEMBL12005319 | 0.86 | EPHX2 (0.49) | NAMPTEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12005322 | 0.86 | EPHX2 (0.49) | NAMPTEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12006366 | 0.86 | EPHX2 (0.61) | KMT2AEPHX2KDM4EALDH1A1POLB | |
| SCHEMBL6863169 | 0.86 | EPHX2 (0.49) | NAMPTEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6863464 | 0.86 | EPHX2 (0.61) | KMT2AEPHX2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
| WO-2011032291-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD . (CA) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | CACNA1G, CACNA1I, CACNA1H | NAMPT 3305/4885SIGMAR1 1667/4885RAB9A 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.