Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 9/20 | 0.45 |
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.45 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137729 | 0.92 | PDE4A (0.63) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL3133797 | 0.84 | PDE4A (0.72) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL3133509 | 0.84 | PDE4A (0.75) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL4463443 | 0.84 | PDE4A (0.42) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL3141261 | 0.84 | PDE4A (0.71) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL3137222 | 0.83 | CTSL (0.59) | CDK1CDK2CCNE1CTSLCTSB | |
| SCHEMBL3142430 | 0.82 | CTSL (0.61) | CDK1CDK2CCNE1CTSLCTSB | |
| SCHEMBL3142086 | 0.82 | CTSL (0.61) | CDK1CDK2CCNE1CTSLCTSB | |
| SCHEMBL3131402 | 0.81 | PDE4A (0.58) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL3587110 | 0.81 | CTSL (0.56) | PDE4APDE4BPDE4CPDE4DCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383767-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002098878-A1 | TRIFLUOROMETHYLPURINES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-12-12 | — | — | WO | claimed |