Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | TOP2A | P11388 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866177 | 0.85 | CXCR2 (0.46) | CXCR2RPS6KA3DAOCTSBMAOB | |
| SCHEMBL6859610 | 0.85 | CXCR2 (0.46) | CXCR2RPS6KA3MAOBSCN9AMEN1 | |
| SCHEMBL841338 | 0.82 | CXCR2 (0.66) | CXCR2DAOCTSBMAOBSCN9A | |
| SCHEMBL6868927 | 0.80 | SCN9A (0.58) | CXCR2DAOMAOBSCN9ATOP2A | |
| SCHEMBL6865826 | 0.80 | DAO (0.49) | CXCR2DAOSCN9AMEN1KMT2A | |
| SCHEMBL6859583 | 0.79 | USP2 (0.54) | CXCR2MAOBSCN9AMEN1KMT2A | |
| SCHEMBL6864187 | 0.79 | KMT2A (0.60) | CXCR2DAOCTSBMAOBTOP2A | |
| SCHEMBL4236680 | 0.79 | CXCR2 (0.57) | CXCR2CTSBTOP2AMEN1KMT2A | |
| SCHEMBL6863822 | 0.78 | CXCR2 (0.56) | CXCR2 | |
| SCHEMBL842322 | 0.77 | CXCR2 (0.70) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |