SCHEMBL6865826

SCHEMBL6865826

Nc1nc2[nH]c(SCc3ccc(Cl)c(Cl)c3)nc(=O)c2s1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.49
CYP1A2 P05177 2/20 0.48
CXCR2 P25025 2/20 0.46
LMNA P02545 2/20 0.44
SCN9A Q15858 2/20 0.44
DHODH Q02127 1/20 0.43
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
USP2 O75604 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
CYP2D6 P10635 1/20 0.40
HIF1A Q16665 1/20 0.40
MAPT P10636 1/20 0.39
CASP3 P42574 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4227284 0.87 MAPT (0.45) DAOCYP1A2CXCR2LMNASCN9A
SCHEMBL6864187 0.85 KMT2A (0.60) DAOCXCR2LMNAMEN1KMT2A
SCHEMBL6866177 0.85 CXCR2 (0.46) DAOCXCR2LMNASCN9AMEN1
SCHEMBL841338 0.82 CXCR2 (0.66) DAOCXCR2LMNASCN9AMAPT
SCHEMBL6865137 0.81 HPGD (0.50) CXCR2LMNASCN9AMEN1KMT2A
SCHEMBL6859583 0.81 USP2 (0.54) CXCR2LMNASCN9AMEN1KMT2A
SCHEMBL6866758 0.81 MEN1 (0.57) CXCR2LMNAMEN1KMT2AL3MBTL1
SCHEMBL6859610 0.80 CXCR2 (0.46) CXCR2LMNASCN9AMEN1KMT2A
SCHEMBL6864099 0.80 CXCR2 (0.46) DAOCXCR2LMNASCN9AMEN1
SCHEMBL6868927 0.80 SCN9A (0.58) DAOCXCR2SCN9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6806273-B1 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS ASTRAZENECA AB (SE) 2004-10-19 US claimed
EP-1104425-B1 NOVEL THIAZOLOPYRIMIDINE COMPOUNDS ASTRAZENECA AB (SE) 2003-01-29 EP claimed
US-6806273-B1 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS ASTRAZENECA AB (SE) 2004-10-19 US disclosed
EP-1104425-B1 NOVEL THIAZOLOPYRIMIDINE COMPOUNDS ASTRAZENECA AB (SE) 2003-01-29 EP disclosed