Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869126 | 0.96 | PARP1 (0.48) | PARP1PARP2NPY5R | |
| SCHEMBL6873048 | 0.86 | PARP1 (0.47) | PARP1NPY5R | |
| SCHEMBL7417491 | 0.86 | NPY5R (0.45) | PARP1PARP2NPY5R | |
| SCHEMBL6584369 | 0.85 | PARP1 (0.50) | PARP1PARP2 | |
| SCHEMBL6873874 | 0.84 | PARP1 (0.46) | PARP1NPY5R | |
| SCHEMBL5620810 | 0.84 | PARP1 (0.64) | PARP1PARP2 | |
| SCHEMBL6874969 | 0.84 | PARP1 (0.51) | PARP1NPY5R | |
| SCHEMBL6873342 | 0.82 | PARP1 (0.46) | PARP1PARP2 | |
| SCHEMBL6864630 | 0.82 | PARP1 (0.49) | PARP1NPY5R | |
| SCHEMBL6864445 | 0.81 | PARP1 (0.46) | PARP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |