Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873874 | 0.96 | PARP1 (0.46) | PARP1NAMPTNPY5RHTR2B | |
| SCHEMBL6874969 | 0.88 | PARP1 (0.51) | PARP1NPY5R | |
| SCHEMBL7409990 | 0.86 | PARP1 (0.43) | PARP1NAMPTNPY5RHTR2B | |
| SCHEMBL6869126 | 0.85 | PARP1 (0.48) | PARP1NPY5R | |
| SCHEMBL6869623 | 0.85 | PARP1 (0.49) | PARP1NAMPTNPY5R | |
| SCHEMBL6873048 | 0.84 | PARP1 (0.47) | PARP1NPY5R | |
| SCHEMBL6869369 | 0.84 | PARP1 (0.49) | PARP1NPY5R | |
| SCHEMBL5621895 | 0.82 | PARP1 (0.71) | PARP1 | |
| SCHEMBL6864586 | 0.82 | PARP1 (0.45) | PARP1NPY5R | |
| SCHEMBL6864445 | 0.81 | PARP1 (0.46) | PARP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |