SCHEMBL6864610

SCHEMBL6864610

OCCN(CCN(Cc1ccccn1)Cc1ccccn1)Cc1ccccn1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.79
MAPT P10636 1/20 0.79
LIN28A Q9H9Z2 1/20 0.79
TDP1 Q9NUW8 1/20 0.79
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
KCNA5 P22460 1/20 0.44
KMT2A Q03164 1/20 0.42
TERT O14746 1/20 0.41
APP P05067 1/20 0.41
HTT P42858 1/20 0.41
CDK1 P06493 1/20 0.40
HRH1 P35367 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8211629 0.98 SMN1; SMN2 (0.75) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL8211498 0.96 SMN1; SMN2 (0.72) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL3739691 0.96 SMN1; SMN2 (0.78) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL28498331 0.96 SMN1; SMN2 (0.71) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
Hydrochloric Acid SCHEMBL4011611 0.95 SMN1; SMN2 (0.75) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL29427509 0.89 TDP1 (1.00) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL231092 0.89 TDP1 (1.00) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL8508012 0.88 SMN1; SMN2 (0.61) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL10609540 0.87 TDP1 (0.96) SMN1; SMN2MAPTLIN28ATDP1CYP1A2
SCHEMBL26521138 0.86 SMN1; SMN2 (0.72) SMN1; SMN2MAPTLIN28ATDP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 US disclosed
US-11649222-B2 Compounds UNIVERSITETET I OSLO (NO) 2023-05-16 US disclosed
EP-3978488-A1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Universitetet I Oslo (NO) 2022-04-06 EP disclosed
EP-3978488-A1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION Universitetet I Oslo (NO) 2022-04-06 EP disclosed
US-20210221791-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2021-07-22 US disclosed
US-20210221791-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2021-07-22 US disclosed
EP-3497095-B1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION UNIV OSLO (NO) 2021-07-14 EP disclosed
EP-3497095-B1 ZINC CHELATING COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION UNIV OSLO (NO) 2021-07-14 EP disclosed
US-10961223-B2 Compounds UNIVERSITETET I OSLO (NO) 2021-03-30 US disclosed
US-10961223-B2 Compounds UNIVERSITETET I OSLO (NO) 2021-03-30 US disclosed
US-20190284167-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2019-09-19 US disclosed
US-20190284167-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2019-09-19 US disclosed
WO-2018033719-A1 COMPOUNDS UNIVERSITETET I OSLO (NO) 2018-02-22 WO disclosed
EP-1008645-B1 Detergent bleaching compositions UNILEVER PLC (GB) 2004-07-21 EP disclosed
US-6165963-A Detergent bleaching composition comprising pentadentate ligand derivatives UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2000-12-26 US disclosed
EP-1008645-A1 Detergent bleaching compositions UNILEVER PLC (GB) 2000-06-14 EP disclosed
WO-2000027975-A1 DETERGENT BLEACHING COMPOSITION UNILEVER PLC (GB) 2000-05-18 WO disclosed
US-6022490-A FOR ACTIVATING PEROXY BLEACH LEVER BROTHERS COMPANY (US) 2000-02-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649222-B2 Compounds SLC30A6, SLC39A11, SLC39A3 SMN1; SMN2 3219/4885MAPT 4706/4885LIN28A 3489/4885
US-10961223-B2 Compounds SLC30A6, SLC39A11, SLC30A5 SMN1; SMN2 3067/4885MAPT 4738/4885LIN28A 3418/4885
US-20190284167-A1 COMPOUNDS SLC30A6, SLC39A11, SLC30A5 SMN1; SMN2 3067/4885MAPT 4738/4885LIN28A 3418/4885
US-20210221791-A1 COMPOUNDS SLC30A6, SLC30A5, SLC39A11 SMN1; SMN2 2917/4885MAPT 4862/4885LIN28A 2835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.