Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355744 | 1.00 | ACACB (0.54) | ACACBPARP10ITGB3ITGA2BPPARA | |
| SCHEMBL158881 | 0.88 | ITGB3 (0.64) | ACACBPARP10ITGB3ITGA2BPPARA | |
| SCHEMBL13780264 | 0.88 | PARP10 (0.54) | ACACBPARP10ITGB3ITGA2BPPARA | |
| SCHEMBL2036599 | 0.88 | ITGB3 (0.64) | ACACBPARP10ITGB3ITGA2BPPARA | |
| SCHEMBL158880 | 0.88 | ITGB3 (0.64) | ACACBPARP10ITGB3ITGA2BPPARA | |
| SCHEMBL13663555 | 0.88 | PARP10 (0.54) | ACACBPARP10ITGB3ITGA2BPPARA | |
| Hydrochloric Acid SCHEMBL6775332 | 0.87 | ITGB3 (0.62) | ACACBITGB3ITGA2BPPARA | |
| SCHEMBL15593940 | 0.87 | ACACB (0.51) | ACACBPARP10ITGB3ITGA2BMEN1 | |
| Hydrochloric Acid SCHEMBL14485333 | 0.87 | ITGB3 (0.62) | ACACBITGB3ITGA2BPPARA | |
| Hydrochloric Acid SCHEMBL14485335 | 0.87 | ITGB3 (0.62) | ACACBITGB3ITGA2BPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017209-A1 | USE OF MELANOCORTINS TO TREAT DYSLIPIDEMIA | IPSEN PHARMA S.A.S. (FR) | 2011-02-10 | — | — | WO | disclosed |
| WO-2009061411-A2 | USE MELANOCORTINS TO TREAT INSULIN SENSITIVITY | IPSEN PHARMA S.A.S. (FR) | 2009-05-14 | — | — | WO | disclosed |
| US-7186715-B2 | Piperazine- and piperidine-derivatives as melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-03-06 | — | — | US | disclosed |
| WO-2007008684-A2 | LIGANDS OF MELANOCORTIN RECEPTORS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S. (FR) | 2007-01-18 | — | — | WO | disclosed |
| US-7157463-B2 | Substituted piperidines/piperazines as melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-01-02 | — | — | US | disclosed |