Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.76 |
| ▸ | MMP3 | P08254 | 10/20 | 0.76 |
| ▸ | MMP13 | P45452 | 10/20 | 0.76 |
| ▸ | MMP7 | P09237 | 7/20 | 0.76 |
| ▸ | MMP9 | P14780 | 8/20 | 0.66 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.66 |
| ▸ | MMP2 | P08253 | 6/20 | 0.65 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758669 | 1.00 | MMP1 (0.76) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6268904 | 0.91 | MMP1 (0.76) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6270548 | 0.86 | MMP1 (1.00) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7347544 | 0.84 | MMP1 (0.57) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7349146 | 0.84 | MMP1 (0.57) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7532596 | 0.83 | MMP1 (0.73) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7532601 | 0.83 | MMP1 (0.73) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7923021 | 0.82 | MMP1 (0.75) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7923015 | 0.82 | MMP1 (0.75) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6268928 | 0.82 | MMP1 (0.75) | MMP1MMP3MMP13MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095936-B1 | Intermediates useful for the preparation of metallproteinase inhibitors | AGOURON PHARMA (US) | 2004-11-24 | — | — | EP | disclosed |
| US-6500948-B1 | SUCH AS N-HYDROXY-4-(4-((PYRID-4-YL)OXY)BENZENESULFONYL)-2,2-DIMETHYL-TETRAHYDRO-2H -1,4-THIAZINE-3-CARBOXYLIC ACID | AGOURON PHARMACEUTICALS, INC. | 2002-12-31 | — | — | US | disclosed |
| EP-0874830-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020824-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1997-06-12 | — | — | WO | disclosed |