Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.58 |
| ▸ | CX3CR1 | P49238 | 15/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999929 | 0.90 | CXCR2 (0.53) | CXCR2CX3CR1PAK4 | |
| SCHEMBL6859484 | 0.87 | CXCR2 (0.72) | CXCR2CX3CR1 | |
| SCHEMBL6865679 | 0.87 | CXCR2 (0.65) | CXCR2CX3CR1PAK4 | |
| SCHEMBL6864129 | 0.85 | CXCR2 (0.72) | CXCR2CX3CR1 | |
| SCHEMBL6859589 | 0.84 | CXCR2 (0.73) | CXCR2CX3CR1 | |
| SCHEMBL6864151 | 0.82 | CX3CR1 (0.51) | CXCR2CX3CR1PAK4 | |
| SCHEMBL6866008 | 0.82 | CXCR2 (0.70) | CXCR2CX3CR1 | |
| SCHEMBL6866794 | 0.81 | CXCR2 (0.65) | CXCR2CX3CR1 | |
| SCHEMBL5232021 | 0.78 | CXCR2 (0.67) | CXCR2CX3CR1 | |
| SCHEMBL5232013 | 0.78 | CXCR2 (0.67) | CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | claimed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6806273-B1 | 5-THIO-THIAZOLO(4,5-D)PYRIMIDIN-7-YL DERIVATIVES; CHEMOKINE RECEPTOR (ESPECIALLY CXCR2) ACTIVITY MODULATORS | ASTRAZENECA AB (SE) | 2004-10-19 | — | — | US | disclosed |
| EP-1104425-B1 | NOVEL THIAZOLOPYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |