Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 14/20 | 0.42 |
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867032 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL6868092 | 0.91 | KDM4E (0.44) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL6868087 | 0.91 | KDM4E (0.44) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL13793238 | 0.82 | MCHR1 (0.61) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878628 | 0.81 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL6878632 | 0.81 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL27651782 | 0.78 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BHPGD | |
| SCHEMBL6880622 | 0.78 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6880618 | 0.78 | MCHR1 (0.44) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6455462 | 0.77 | MCHR1 (0.68) | MCHR1ADRA2AHRH1HTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |