Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 15/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.40 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868087 | 1.00 | KDM4E (0.44) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6867032 | 0.91 | MCHR1 (0.42) | KDM4EMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6867035 | 0.91 | MCHR1 (0.42) | KDM4EMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL13793609 | 0.83 | MCHR1 (0.58) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6873894 | 0.82 | MCHR1 (0.37) | MCHR1ADRA2AHRH1HTR2BALDH1A1 | |
| SCHEMBL6873889 | 0.82 | MCHR1 (0.37) | MCHR1ADRA2AHRH1HTR2BALDH1A1 | |
| SCHEMBL6876589 | 0.79 | KDM4E (0.46) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6876584 | 0.79 | KDM4E (0.46) | KDM4EGAAMCHR1ADRA2AHRH1 | |
| SCHEMBL6878632 | 0.79 | MCHR1 (0.44) | KDM4EMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878628 | 0.79 | MCHR1 (0.44) | KDM4EMCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |