Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 15/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866728 | 0.91 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL6873122 | 0.91 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL7037721 | 0.90 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL7043911 | 0.88 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18329262 | 0.83 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL29618010 | 0.83 | GABRG2 (0.69) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL20389329 | 0.82 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL6868907 | 0.81 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL6869006 | 0.81 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL6870825 | 0.81 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337535-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2004-06-09 | — | — | EP | disclosed |
| EP-1337535-A2 | BENZODIAZEPINE DERIVATIVES AS GABA A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040487-A2 | BENZODIAZEPINE DERIVATIVES AS GABA A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |