Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.55 |
| ▸ | HTR2B | P41595 | 6/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867124 | 1.00 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6456095 | 0.89 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6456083 | 0.89 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458320 | 0.85 | MCHR1 (0.57) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458333 | 0.85 | MCHR1 (0.57) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6828396 | 0.85 | ACACB (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6461468 | 0.85 | ACACB (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6461475 | 0.85 | ACACB (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874839 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874836 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |