Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 11/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867234 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2APKMGAAADRA1A | |
| SCHEMBL6467491 | 0.88 | TP53 (0.47) | MCHR1ADRA2AGAA | |
| SCHEMBL6467487 | 0.88 | TP53 (0.47) | MCHR1ADRA2AGAA | |
| SCHEMBL6874492 | 0.88 | EPHX1 (0.54) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6874485 | 0.88 | EPHX1 (0.54) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6872406 | 0.87 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6868351 | 0.87 | USP30 (0.46) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6872410 | 0.87 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6868346 | 0.87 | USP30 (0.46) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6457784 | 0.87 | EPHX2 (0.50) | MCHR1ADRA2AADRA1AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |