Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861474 | 0.85 | KDM4E (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6865931 | 0.78 | ERN1 (0.46) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3124246 | 0.75 | HMGCR (0.47) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7510589 | 0.74 | MCL1 (0.40) | HTTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30601583 | 0.71 | HTT (0.49) | HTTSMN1; SMN2LMNAHPGDTSHR | |
| SCHEMBL13304014 | 0.71 | HTT (0.49) | HTTSMN1; SMN2LMNAHPGDTSHR | |
| SCHEMBL12435962 | 0.70 | MAPT (0.49) | HTTSMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL20612885 | 0.69 | TSHR (0.48) | HTTSMN1; SMN2LMNAHPGDTSHR | |
| SCHEMBL30761018 | 0.69 | GAA (0.39) | SMN1; SMN2TSHRMAPTPOLBKMT2A | |
| SCHEMBL23079291 | 0.68 | GABRA1 (0.48) | LMNAHPGDHSD17B10MCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095040-B1 | NEW BENZOXAZOLES WITH PDE-INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-31 | — | — | EP | disclosed |
| US-6376485-B1 | SELECTIVE PHOSPHODIESTERASE INHIBITORS FOR TREATING ASTHMA, BRONCHITIS, AND EMPHYSEMA; HIGH BIOAVAILABILITY AND LOW TOXICITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2002-04-23 | — | — | US | disclosed |