SCHEMBL6867907

SCHEMBL6867907

[CH2]Oc1ccc2oc(C(=O)OCC)cc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.54
MAPT P10636 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
USP2 O75604 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
KMT2A Q03164 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
HSD17B10 Q99714 1/20 0.50
FLT3 P36888 1/20 0.49
TAS1R3 Q7RTX0 2/20 0.48
TAS1R1 Q7RTX1 2/20 0.48
CA12 O43570 1/20 0.48
CA2 P00918 1/20 0.48
CA3 P07451 1/20 0.48
CA4 P22748 1/20 0.48
CA6 P23280 1/20 0.48
CA7 P43166 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8118515 0.87 MAOB (0.55) MAOBMAPTKDM4EMEN1USP2
SCHEMBL648621 0.87 MAOB (0.70) MAOBMAPTKDM4EALDH1A1HPGD
SCHEMBL18591911 0.84 MAOB (0.52) MAOBMAPTKDM4EMEN1USP2
SCHEMBL18611964 0.84 MAOB (0.52) MAOBALDH1A1FLT3TAS1R3TAS1R1
SCHEMBL10507360 0.83 CA12 (0.54) MAOBALDH1A1HPGDCA12CA9
SCHEMBL18591926 0.83 MAOB (0.51) MAOBFLT3TAS1R3TAS1R1AKR1B1
SCHEMBL1066982 0.82 TAS1R3 (0.56) MAOBMAPTKDM4EMEN1USP2
SCHEMBL25777700 0.82 CA12 (0.59) MAOBMAPTKDM4EMEN1USP2
SCHEMBL1473963 0.81 MAOB (0.68) MAOBMAPTKDM4EMEN1USP2
SCHEMBL30493800 0.81 FLT3 (0.61) MAOBMAPTKDM4EMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1149094-B1 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2004-04-21 EP disclosed
US-6376491-B1 BENZOFURAN DERIVATIVES FOR TREATMENT OR PREVENTION OF MYCOSIS IN MAMMALS BASILEA PHARMACEUTICA AG (CH) 2002-04-23 US disclosed
EP-1149094-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS Basilea Pharmaceutica AG (CH) 2001-10-31 EP disclosed
WO-2000037464-A2 4-(AMINOALKOXY)BENZOFURANS AS N-MYRISTOYLTRANSFERASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2000-06-29 WO disclosed