Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.46 |
| ▸ | FAAH | O00519 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | AADAC | P22760 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6454253 | 0.91 | MMP12 (0.62) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6531648 | 0.90 | MMP12 (0.65) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6532143 | 0.89 | MMP12 (0.58) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6452240 | 0.86 | MMP12 (0.60) | MMP12MMP13EPHX2ABL1CYP2D6 | |
| SCHEMBL6530795 | 0.84 | MMP12 (0.58) | MMP12MMP13EPHX2ABL1CYP2D6 | |
| SCHEMBL6879366 | 0.82 | MMP12 (0.64) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6525522 | 0.82 | MMP12 (0.64) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6874089 | 0.82 | MMP12 (0.57) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6874086 | 0.82 | MMP12 (0.57) | MMP12MMP13EPHX2FAAHABL1 | |
| SCHEMBL6879557 | 0.82 | MMP12 (0.58) | MMP12MMP13EPHX2FAAHABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394159-A1 | New thiophene derivatives, process for their preparation and pharmaceutical compositions containing them | Warner-Lambert Company LLC (US) | 2004-03-03 | — | — | EP | disclosed |