Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867145 | 0.99 | ADORA2A (0.71) | ADORA2AMAPK1MEN1ALDH1A1MAPT | |
| SCHEMBL6871339 | 0.85 | ADORA2A (0.68) | ADORA2AALDH1A1 | |
| SCHEMBL6869244 | 0.84 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6867568 | 0.84 | ADORA2A (1.00) | ADORA2AHPGD | |
| SCHEMBL6867704 | 0.84 | ADORA2A (0.67) | ADORA2AALDH1A1HPGD | |
| SCHEMBL6870681 | 0.83 | ADORA2A (0.49) | ADORA2AMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6871467 | 0.83 | ADORA2A (0.98) | ADORA2AHPGD | |
| SCHEMBL6871623 | 0.83 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6869099 | 0.83 | ADORA2A (0.98) | ADORA2AHPGD | |
| SCHEMBL6869091 | 0.83 | ADORA2A (0.98) | ADORA2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6506772-B1 | Pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are the adenosine receptor. | HOFFMANN-LA ROCHE INC. | 2003-01-14 | — | — | US | disclosed |