Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868350 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879434 | 0.89 | MCHR1 (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879428 | 0.89 | MCHR1 (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874857 | 0.88 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874864 | 0.88 | MCHR1 (0.45) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6876416 | 0.85 | HPGD (0.61) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6876408 | 0.85 | HPGD (0.61) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462963 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6462965 | 0.85 | MCHR1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458588 | 0.83 | MCHR1 (0.65) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |