Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 17/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.50 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | HTR2B | P41595 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876416 | 1.00 | HPGD (0.61) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6866959 | 0.90 | MCHR1 (0.56) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6866957 | 0.90 | MCHR1 (0.56) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6877214 | 0.88 | MCHR1 (0.53) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6877218 | 0.88 | MCHR1 (0.53) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878080 | 0.88 | NPC1 (0.55) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6873330 | 0.85 | MCHR1 (0.48) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6873326 | 0.85 | MCHR1 (0.48) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6868341 | 0.85 | MCHR1 (0.47) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6868350 | 0.85 | MCHR1 (0.47) | HPGDMCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |