Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.72 |
| ▸ | HRH1 | P35367 | 5/20 | 0.72 |
| ▸ | HTR2B | P41595 | 4/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868500 | 1.00 | MCHR1 (1.00) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| Hydrochloric Acid SCHEMBL6457974 | 0.99 | MCHR1 (0.98) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| Hydrochloric Acid SCHEMBL6457983 | 0.99 | MCHR1 (0.98) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464322 | 0.90 | MCHR1 (0.81) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464331 | 0.90 | MCHR1 (0.81) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879037 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874799 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879042 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874796 | 0.88 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878436 | 0.88 | CNR1 (0.83) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | disclosed |
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |