Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868813 | 1.00 | KDM4E (0.52) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6875133 | 0.99 | KDM4E (0.50) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6875141 | 0.99 | KDM4E (0.50) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6874577 | 0.87 | LMNA (0.52) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6874583 | 0.87 | LMNA (0.52) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6879766 | 0.85 | KDM4E (0.45) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6877623 | 0.85 | MCHR1 (0.43) | KDM4ELMNASMN1; SMN2MCHR1ADRA2A | |
| SCHEMBL6879774 | 0.85 | KDM4E (0.45) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 | |
| SCHEMBL6877625 | 0.85 | MCHR1 (0.43) | KDM4ELMNASMN1; SMN2MCHR1ADRA2A | |
| SCHEMBL6879770 | 0.85 | KDM4E (0.45) | KDM4ELMNASMN1; SMN2MCHR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |