Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 14/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869030 | 1.00 | KMT2A (0.52) | KMT2ANPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6877658 | 0.90 | EPHX2 (0.44) | KMT2ANPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6877651 | 0.90 | EPHX2 (0.44) | KMT2ANPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6877825 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6877832 | 0.90 | MCHR1 (0.48) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6874965 | 0.89 | MCHR1 (0.47) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6868709 | 0.89 | NPC1 (0.53) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6874958 | 0.89 | MCHR1 (0.47) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6868705 | 0.89 | NPC1 (0.53) | NPC1RAB9AMCHR1ADRA2AADRA1A | |
| SCHEMBL6876848 | 0.89 | MCHR1 (0.42) | KMT2AMCHR1ADRA2AADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |