Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868709 | 1.00 | NPC1 (0.53) | NPC1RAB9APOLBL3MBTL1MCHR1 | |
| SCHEMBL6874965 | 0.93 | MCHR1 (0.47) | NPC1RAB9APOLBL3MBTL1MCHR1 | |
| SCHEMBL6874958 | 0.93 | MCHR1 (0.47) | NPC1RAB9APOLBL3MBTL1MCHR1 | |
| SCHEMBL6875347 | 0.91 | MCHR1 (0.43) | NPC1RAB9APOLBL3MBTL1MCHR1 | |
| SCHEMBL6875350 | 0.91 | MCHR1 (0.43) | NPC1RAB9APOLBL3MBTL1MCHR1 | |
| SCHEMBL6878918 | 0.91 | MCHR1 (0.48) | NPC1RAB9APOLBMCHR1ADRA2A | |
| SCHEMBL6878910 | 0.91 | MCHR1 (0.48) | NPC1RAB9APOLBMCHR1ADRA2A | |
| SCHEMBL6866729 | 0.89 | MCHR1 (0.42) | NPC1RAB9APOLBMCHR1ADRA2A | |
| SCHEMBL6866736 | 0.89 | MCHR1 (0.42) | NPC1RAB9APOLBMCHR1ADRA2A | |
| SCHEMBL6869037 | 0.89 | KMT2A (0.52) | NPC1RAB9APOLBMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |