Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867673 | 0.96 | ADORA2A (0.48) | ADORA2AF2HSF1HPGDTLR8 | |
| SCHEMBL6871315 | 0.94 | ADORA2A (0.50) | ADORA2AHSF1HPGDPDE11A | |
| SCHEMBL6871398 | 0.89 | ADORA2A (0.53) | ADORA2AHSF1HPGDADORA2BADORA1 | |
| SCHEMBL6863143 | 0.88 | ADORA2A (0.58) | ADORA2AHSF1HPGDPDE11AADORA2B | |
| SCHEMBL6866988 | 0.87 | ADORA2A (0.60) | ADORA2AHSF1HPGDPDE11AADORA2B | |
| SCHEMBL6867158 | 0.87 | ADORA2A (0.43) | ADORA2AF2 | |
| SCHEMBL6867837 | 0.86 | ADORA2A (0.52) | ADORA2AHSF1HPGDPDE11AADORA2B | |
| SCHEMBL6868365 | 0.85 | ADORA2A (0.44) | ADORA2AHPGDPDE11AADORA2BADORA1 | |
| SCHEMBL6869890 | 0.83 | ADORA2A (0.48) | ADORA2AF2PDE11AADORA2BADORA1 | |
| SCHEMBL6870562 | 0.83 | ADORA2A (0.48) | ADORA2AF2PDE11AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347974-B1 | AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |