Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869275 | 1.00 | MAPK14 (0.54) | MAPK14NPC1RAB9AEPHX2MCHR1 | |
| SCHEMBL6876089 | 0.91 | TSHR (0.57) | MAPK14NPC1RAB9AEPHX2MCHR1 | |
| SCHEMBL6876093 | 0.91 | TSHR (0.57) | MAPK14NPC1RAB9AEPHX2MCHR1 | |
| Hydrochloric Acid SCHEMBL6460685 | 0.91 | MAPK14 (0.45) | MAPK14NPC1RAB9AMCHR1ADRA2A | |
| Hydrochloric Acid SCHEMBL6460688 | 0.91 | MAPK14 (0.45) | MAPK14NPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6872847 | 0.89 | EPHX2 (0.47) | MAPK14EPHX2MCHR1ADRA2AHRH1 | |
| SCHEMBL6872853 | 0.89 | EPHX2 (0.47) | MAPK14EPHX2MCHR1ADRA2AHRH1 | |
| SCHEMBL6880649 | 0.88 | AURKB (0.41) | MAPK14MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878450 | 0.88 | MAPK8 (0.41) | MAPK14MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878449 | 0.88 | MAPK8 (0.41) | MAPK14MCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |