Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876093 | 1.00 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1MAPK14MCHR1 | |
| SCHEMBL6869275 | 0.91 | MAPK14 (0.54) | TSHRSMN1; SMN2MAPK14MCHR1EPHX2 | |
| SCHEMBL6869279 | 0.91 | MAPK14 (0.54) | TSHRSMN1; SMN2MAPK14MCHR1EPHX2 | |
| Hydrochloric Acid SCHEMBL6460688 | 0.90 | MAPK14 (0.45) | TSHRSMN1; SMN2MAPK14MCHR1ADRA2A | |
| Hydrochloric Acid SCHEMBL6460685 | 0.90 | MAPK14 (0.45) | TSHRSMN1; SMN2MAPK14MCHR1ADRA2A | |
| SCHEMBL6874165 | 0.90 | MCHR1 (0.45) | TSHRSMN1; SMN2MAPK14MCHR1ADRA2A | |
| SCHEMBL6874169 | 0.90 | MCHR1 (0.45) | TSHRSMN1; SMN2MAPK14MCHR1ADRA2A | |
| SCHEMBL6877574 | 0.89 | ALDH1A1 (0.63) | TSHRSMN1; SMN2ALDH1A1MAPK14MCHR1 | |
| SCHEMBL6877567 | 0.89 | ALDH1A1 (0.63) | TSHRSMN1; SMN2ALDH1A1MAPK14MCHR1 | |
| SCHEMBL6460215 | 0.88 | MCHR1 (0.47) | TSHRSMN1; SMN2ALDH1A1MAPK14MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |