Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6870505 | 0.99 | DRD2 (0.70) | DRD2DRD4DRD3KCNH2HTR7 | |
| SCHEMBL6867106 | 0.95 | DRD2 (0.78) | DRD2DRD4DRD3KCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7653425 | 0.94 | DRD2 (0.77) | DRD2DRD4DRD3KCNH2SIGMAR1 | |
| SCHEMBL31651583 | 0.86 | DRD2 (0.84) | DRD2DRD4DRD3KCNH2HTR7 | |
| SCHEMBL26117575 | 0.86 | DRD2 (0.84) | DRD2DRD4DRD3KCNH2HTR7 | |
| SCHEMBL30767216 | 0.86 | KCNH2 (0.90) | DRD2KCNH2HTR7SIGMAR1HTR1A | |
| SCHEMBL5178283 | 0.86 | KCNH2 (0.67) | DRD2DRD4DRD3KCNH2SIGMAR1 | |
| SCHEMBL7661464 | 0.85 | DRD2 (0.61) | DRD2DRD4DRD3HTR7SIGMAR1 | |
| SCHEMBL5177912 | 0.85 | KCNH2 (0.65) | DRD2DRD4DRD3KCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7658247 | 0.85 | KCNH2 (0.88) | DRD2KCNH2HTR7SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1168714-C | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | ʵ | 2004-09-29 | — | — | CN | claimed |
| CN-1318052-A | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | RANBAXY LAB LTD (IN) | 2001-10-17 | — | — | CN | claimed |
| US-6812344-B1 | SYTHESIS OF COMPOUNDS FOR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2004-11-02 | — | — | US | disclosed |
| CN-1168714-C | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | ʵ | 2004-09-29 | — | — | CN | disclosed |
| US-6420559-B1 | THE COMPOUNDS ARE USEFUL FOR TREATMENT OF DISEASE CONDITIONS, SUCH AS PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. | RANBAXY LABORATORIES LIMITED (IN) | 2002-07-16 | — | — | US | disclosed |
| US-6410735-B1 | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS; BENGIN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2002-06-25 | — | — | US | disclosed |
| EP-1097134-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES, LTD. (IN) | 2001-05-09 | — | — | EP | disclosed |
| US-6083950-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY | RANBAXY LABORATORIES LIMITED (IN) | 2000-07-04 | — | — | US | disclosed |
| WO-2000005206-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | disclosed |
| WO-2000005205-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | disclosed |