Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.69 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872050 | 0.85 | PARP1 (0.70) | PARP1PARP2 | |
| SCHEMBL630259 | 0.82 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL7702651 | 0.82 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL633643 | 0.82 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL6864453 | 0.82 | PARP1 (0.71) | PARP1PARP2MAP4K4CSF1RPIM1 | |
| SCHEMBL6872238 | 0.81 | PARP1 (0.68) | PARP1PARP2 | |
| SCHEMBL6869625 | 0.79 | PARP1 (0.69) | PARP1PARP2 | |
| SCHEMBL7518634 | 0.79 | PARP1 (0.48) | PARP1PARP2 | |
| SCHEMBL7518847 | 0.79 | PARP1 (0.48) | PARP1PARP2 | |
| SCHEMBL7415820 | 0.79 | PARP1 (0.56) | PARP1PARP2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |