Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697951 | 0.90 | HTR3A (0.67) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4700653 | 0.85 | HTR3A (0.69) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL6867170 | 0.84 | HTR3A (0.67) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4700613 | 0.81 | CHRNA7 (0.70) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL373021 | 0.81 | HTR3A (1.00) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4703304 | 0.80 | HTR3A (0.73) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4700525 | 0.79 | HTR3A (0.60) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4699915 | 0.77 | HTR3A (0.69) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4698915 | 0.77 | HTR3A (0.69) | HTR3ACHRNA7KCNH2CHRM4CHRM5 | |
| SCHEMBL4700913 | 0.76 | HTR3A (0.67) | HTR3ACHRNA7KCNH2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809094-B2 | N-FUSED HETERCYCLO-1,4- OR -1,5- DIAZABICYCLO DERIVATIVES; NICOTINIC RECEPTOR AGONISTS; CENTRAL NERVOUS SYSTEM (CNS) | PFIZER INC | 2004-10-26 | — | — | US | claimed |