Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.35 |
| ▸ | PRKCG | P05129 | 3/20 | 0.35 |
| ▸ | PRKCB | P05771 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | PRKCA | P17252 | 3/20 | 0.35 |
| ▸ | PRKCH | P24723 | 3/20 | 0.35 |
| ▸ | PRKCI | P41743 | 3/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 6/20 | 0.33 |
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68362 | 0.82 | PIK3CG (0.37) | CDK5GSK3BCDK2CDK4PIK3CA | |
| SCHEMBL67957 | 0.74 | BRAF (0.41) | BRAFZAP70PRKD3PRKCGPRKCB | |
| SCHEMBL67395 | 0.71 | BRAF (0.42) | BRAFJAK2ZAP70PRKD3PRKCG | |
| SCHEMBL68750 | 0.71 | BRAF (0.44) | BRAFJAK2ZAP70PRKD3PRKCG | |
| SCHEMBL68681 | 0.71 | BRAF (0.55) | BRAFZAP70PRKD3PRKCGPRKCB | |
| SCHEMBL68741 | 0.69 | BRAF (0.44) | BRAFJAK2ZAP70PRKD3PRKCG | |
| SCHEMBL84579 | 0.64 | DGAT1 (0.39) | BRAFPIK3CA | |
| SCHEMBL68603 | 0.64 | TNIK (0.39) | BRAF | |
| SCHEMBL67109 | 0.63 | TNIK (0.43) | BRAFPIK3CA | |
| SCHEMBL67857 | 0.63 | BRAF (0.38) | BRAFJAK2ZAP70PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | BRAF 1/4885JAK2 658/4885ZAP70 876/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | BRAF 1/4885JAK2 571/4885ZAP70 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.