Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 9/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687079 | 0.90 | PTGER3 (0.43) | CTSACYP26A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL687355 | 0.86 | CTSA (0.40) | CTSACYP26A1KEAP1NFE2L2 | |
| SCHEMBL688110 | 0.83 | MEN1 (0.49) | CTSACYP26A1KEAP1NFE2L2KDM4E | |
| SCHEMBL27762463 | 0.83 | PTGER3 (0.44) | CTSACYP26A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL687932 | 0.80 | EGLN1 (0.44) | CTSAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL686693 | 0.80 | PTGER3 (0.42) | CTSACYP26A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL687511 | 0.79 | MEN1 (0.46) | CTSACYP26A1KEAP1NFE2L2KDM4E | |
| SCHEMBL687697 | 0.79 | CTSA (0.40) | CTSAKDM4EALDH1A1GAA | |
| SCHEMBL688357 | 0.79 | POLB (0.41) | CTSACYP26A1KEAP1NFE2L2KDM4E | |
| SCHEMBL687794 | 0.78 | MEN1 (0.45) | CTSAKEAP1NFE2L2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |