Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688357 | 0.92 | POLB (0.41) | POLBLMNAMAPTMEN1KMT2A | |
| SCHEMBL688110 | 0.92 | MEN1 (0.49) | EGLN1POLBLMNAMAPTMEN1 | |
| SCHEMBL687408 | 0.90 | KMT2A (0.43) | EGLN1POLBLMNAMAPTHTT | |
| SCHEMBL687511 | 0.90 | MEN1 (0.46) | POLBMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL688413 | 0.89 | POLB (0.40) | POLBLMNAMAPTHTTMEN1 | |
| SCHEMBL688248 | 0.88 | POLB (0.39) | POLBLMNAMAPTMEN1KMT2A | |
| SCHEMBL686843 | 0.88 | MAPT (0.47) | POLBLMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL688277 | 0.88 | MEN1 (0.39) | POLBLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL687488 | 0.87 | MAPT (0.51) | POLBLMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL687925 | 0.87 | CYP26A1 (0.42) | POLBMEN1KMT2ACTSAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |