Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 9/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | C5 | P01031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687118 | 0.96 | SMN1; SMN2 (0.40) | SMN1; SMN2PTGER3POLBMAPTKMT2A | |
| SCHEMBL687629 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2PTGER3POLBMAPTKMT2A | |
| SCHEMBL688165 | 0.90 | PTGER3 (0.41) | SMN1; SMN2PTGER3CYP1A2 | |
| SCHEMBL687909 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2PTGER3POLBMAPTKMT2A | |
| SCHEMBL687904 | 0.88 | PTGER3 (0.47) | SMN1; SMN2PTGER3POLBMAPTKMT2A | |
| SCHEMBL687251 | 0.86 | PTGER3 (0.42) | SMN1; SMN2PTGER3MAPTCYP1A2ALDH1A1 | |
| SCHEMBL688158 | 0.86 | RXFP1 (0.45) | SMN1; SMN2PTGER3MAPTKMT2ACYP1A2 | |
| SCHEMBL687771 | 0.86 | PTGER3 (0.45) | SMN1; SMN2PTGER3CYP1A2KDM4EALDH1A1 | |
| SCHEMBL687114 | 0.85 | PTGER3 (0.45) | SMN1; SMN2PTGER3POLBMAPTITGB1 | |
| SCHEMBL688250 | 0.85 | PTGER3 (0.45) | SMN1; SMN2PTGER3POLBMAPTITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |