Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 17/20 | 0.62 |
| ▸ | TACR2 | P21452 | 5/20 | 0.45 |
| ▸ | TACR3 | P29371 | 5/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869893 | 0.89 | TRPV4 (0.67) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6870049 | 0.86 | TRPV4 (0.83) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL6870090 | 0.85 | TRPV4 (0.67) | TRPV4TACR2TACR3OPRM1KCNH2 | |
| SCHEMBL6870095 | 0.84 | TRPV4 (0.65) | TRPV4TACR2TACR3OPRM1KCNH2 | |
| SCHEMBL6869969 | 0.80 | TRPV4 (0.73) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| SCHEMBL2514030 | 0.79 | TRPV4 (0.81) | TRPV4TACR2TACR3OPRM1 | |
| SCHEMBL6845575 | 0.78 | TRPV4 (0.83) | TRPV4TACR2TACR3KCNH2CACNA1C | |
| Trifluoroacetic Acid SCHEMBL25197956 | 0.78 | TRPV4 (0.81) | TRPV4TACR2TACR3OPRM1KCNH2 | |
| SCHEMBL6845594 | 0.78 | TRPV4 (0.62) | TRPV4TACR2TACR3OPRM1KCNH2 | |
| SCHEMBL2373423 | 0.77 | TRPV4 (0.61) | TRPV4TACR2TACR3OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119694-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |