Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | F7 | P08709 | 3/20 | 0.44 |
| ▸ | F3 | P13726 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5882857 | 0.90 | PRSS1 (0.49) | GPR119PRSS1PRSS2F7F3 | |
| SCHEMBL6870491 | 0.83 | PRSS1 (0.42) | GPR119PRSS1PRSS2F7F3 | |
| SCHEMBL6874426 | 0.81 | F10 (0.52) | GPR119ALKCETPF10MAPT | |
| SCHEMBL5883650 | 0.80 | PRSS1 (0.53) | PRSS1PRSS2F7F3PRSS3 | |
| SCHEMBL5882153 | 0.80 | PRSS1 (0.59) | PRSS1PRSS2F7F3PRSS3 | |
| SCHEMBL7421141 | 0.79 | PRSS1 (0.50) | GPR119PRSS1PRSS2F7F3 | |
| SCHEMBL5882560 | 0.77 | PRSS1 (0.61) | PRSS1PRSS2F7F3PRSS3 | |
| SCHEMBL5883682 | 0.77 | PRSS1 (0.61) | PRSS1PRSS2F7F3PRSS3 | |
| SCHEMBL5883162 | 0.76 | F10 (0.55) | GPR119PRSS1PRSS2F7F3 | |
| SCHEMBL5882740 | 0.75 | PRSS1 (0.73) | PRSS1PRSS2F7F3PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149069-B1 | PHENYLGLYCINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-25 | — | — | EP | disclosed |