Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074732 | 0.86 | ATR (0.48) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL12133550 | 0.84 | LCK (0.46) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL15951249 | 0.83 | ATR (0.43) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL16533461 | 0.83 | ATR (0.43) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL19384200 | 0.81 | XPO1 (0.44) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL3710643 | 0.81 | MAPKAPK2 (0.45) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL12133539 | 0.81 | ATR (0.44) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL25028777 | 0.80 | METAP1 (0.44) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL31120609 | 0.80 | LCK (0.43) | ATRLCKKMT2ALMNACYP17A1 | |
| SCHEMBL29439638 | 0.80 | METAP1 (0.41) | ATRLCKKMT2ALMNACYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119694-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |