Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402738 | 0.81 | BRD4 (0.49) | FFAR1CTSLCTSBCTSS | |
| SCHEMBL31755970 | 0.81 | BRD4 (0.49) | FFAR1CTSLCTSBCTSS | |
| SCHEMBL5562300 | 0.80 | KAT6A (0.44) | FFAR1CTSLCTSBCTSS | |
| SCHEMBL16595264 | 0.79 | FFAR1 (0.57) | FFAR1CTSLCTSBCTSSHRH3 | |
| SCHEMBL1747192 | 0.76 | FFAR1 (0.78) | FFAR1FAAH | |
| SCHEMBL4768334 | 0.76 | KDM4E (0.53) | FFAR1CTSLCTSBCTSSHRH3 | |
| SCHEMBL1380801 | 0.75 | TDP1 (0.61) | FFAR1 | |
| SCHEMBL18045829 | 0.75 | FOLH1 (0.49) | — | |
| SCHEMBL5262346 | 0.74 | SIRT2 (0.49) | — | |
| SCHEMBL13250326 | 0.74 | TDP1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-A1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066623-A1 | DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |