Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982252 | 0.90 | CYP4F2 (0.50) | TDP1ALDH1A1KMT2AFFAR1 | |
| SCHEMBL10578604 | 0.89 | HDAC1 (0.56) | TDP1ALDH1A1KMT2AL3MBTL1NPC1 | |
| SCHEMBL9196120 | 0.88 | MAPT (0.56) | TDP1KMT2AHDAC2HDAC8HDAC6 | |
| SCHEMBL27586622 | 0.86 | MAPT (0.59) | HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL7058420 | 0.86 | TDP1 (0.50) | TDP1ALDH1A1KEAP1KMT2AL3MBTL1 | |
| SCHEMBL9078410 | 0.85 | ALDH1A1 (0.62) | TDP1ALDH1A1L3MBTL1FFAR1TRPV1 | |
| SCHEMBL29200276 | 0.85 | TDP1 (0.45) | TDP1ALDH1A1KEAP1KMT2AL3MBTL1 | |
| SCHEMBL3590948 | 0.85 | TDP1 (0.49) | TDP1ALDH1A1KEAP1KMT2AL3MBTL1 | |
| SCHEMBL5947113 | 0.85 | FFAR1 (0.66) | FFAR1 | |
| SCHEMBL9077714 | 0.84 | ALDH1A1 (0.50) | TDP1ALDH1A1L3MBTL1HTTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283699-A | Method for synthesizing fluoroalkyl substituted pyrrolidine | 遵义医科大学 | 2023-06-23 | — | — | CN | claimed |
| CN-110590692-A | 6H-1, 3-oxazoline-6-ketone compound and application thereof in drugs for treating attention deficit hyperactivity disorder | 张振亭 | 2019-12-20 | — | — | CN | claimed |
| EP-2897940-B1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2019-05-01 | — | — | EP | claimed |
| CN-109641904-A | The sulphur imido acyl group purine ketone compound that 7- for treating and preventing virus infection replaces | 豪夫迈·罗氏有限公司 | 2019-04-16 | — | — | CN | claimed |
| CN-104958247-B | A kind of body lotion containing nostoc sphaeroids kutz extractive and preparation method thereof | 湖南炎帝生物工程有限公司 | 2018-02-09 | — | — | CN | claimed |
| EP-2299813-B1 | BRANCHED 3- AND 6-SUBSTITUTED QUINOLINES AS CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2015-12-16 | — | — | EP | claimed |
| US-8377955-B2 | Branched 3- and 6-substituted quinolines as CGRP receptors antagonists | Merck, Sharp & Dohme, Corp. (US) | 2013-02-19 | — | — | US | claimed |
| EP-1601674-B1 | Hydroxyalkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-08 | — | — | EP | claimed |
| JP-4712384-B2 | — | — | 2011-06-29 | — | — | JP | claimed |
| US-20110105549-A1 | BRANCHED 3- AND 6-SUBSTITUTED QUINOLINES AS CGRP RECEPTORS ANTAGONISTS | MERCK SHARP & DOHME LLC | 2011-05-05 | — | — | US | claimed |
| US-20060030577-A1 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders | BATTISTA KATHLEEN | 2006-02-09 | — | — | US | claimed |
| EP-1601674-A2 | HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO 4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-12-07 | — | — | EP | claimed |
| US-6946025-B2 | Process for preparing tetra-amide compounds | XEROX CORPORATION (US) | 2005-09-20 | — | — | US | claimed |
| US-20050090690-A1 | Process for preparing tetra-amide compounds | XEROX CORPORATION | 2005-04-28 | — | — | US | claimed |
| CN-1604900-A | 6-aminomorphinane derivatives, method for production and use thereof | ALCASYNN PHARMACEUTICALS GMBH (AT) | 2005-04-06 | — | — | CN | claimed |
| US-20040147520-A1 | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2004-07-29 | — | — | US | claimed |
| US-20040142955-A1 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1receptor mediated disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-07-22 | — | — | US | claimed |
| US-20040138208-A1 | Sulfonylbenzodiazepinone acetamides as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2004-07-15 | — | — | US | claimed |
| WO-2004022558-A2 | HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-03-18 | — | — | WO | claimed |
| CN-1201454-A | Meta-guanidino, ureido, thioureido or azacyclic aminobenzoic acid derivatives as integrin antagonists | SEARLE & CO (US) | 1998-12-09 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142955-A1 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1receptor mediated disorders | OPRL1, GPR4, ADRA1D | TDP1 1396/4885ALDH1A1 196/4885KEAP1 1065/4885 |
| US-20060030577-A1 | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders | OPRL1, ADRA1D, OPRD1 | TDP1 1010/4885ALDH1A1 175/4885KEAP1 966/4885 |
| US-20110105549-A1 | BRANCHED 3- AND 6-SUBSTITUTED QUINOLINES AS CGRP RECEPTORS ANTAGONISTS | GALR3, BDKRB2, CCKBR | TDP1 2818/4885ALDH1A1 2896/4885KEAP1 694/4885 |
| US-20050090690-A1 | Process for preparing tetra-amide compounds | TAF9, TAF5, TAF1 | TDP1 1182/4885ALDH1A1 1723/4885KEAP1 2845/4885 |
| US-20040147520-A1 | Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists | BDKRB2, BDKRB1, PDXK | TDP1 4513/4885ALDH1A1 2366/4885KEAP1 69/4885 |
| US-20040138208-A1 | Sulfonylbenzodiazepinone acetamides as bradykinin antagonists | BDKRB1, BDKRB2, HRH2 | TDP1 3995/4885ALDH1A1 2559/4885KEAP1 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.