Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532256 | 0.93 | SMN1; SMN2 (0.45) | MAPTRHEBSMN1; SMN2HTTSTAT3 | |
| SCHEMBL5521439 | 0.93 | MAPT (0.50) | MAPTRHEBSMN1; SMN2HTTSTAT3 | |
| SCHEMBL5033252 | 0.79 | MAPT (0.50) | MAPTRHEBSMN1; SMN2HTTSTAT3 | |
| SCHEMBL18497724 | 0.75 | MAPT (0.45) | MAPTRHEBSMN1; SMN2HTTSTAT3 | |
| SCHEMBL5513297 | 0.74 | NCF1 (0.54) | SMN1; SMN2HTTSTAT3LMNARAB9A | |
| SCHEMBL18497755 | 0.74 | CNR1 (0.45) | MAPTSMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL3645761 | 0.74 | MAOB (0.51) | SMN1; SMN2LMNARAB9AMAOBKDM4E | |
| SCHEMBL3646897 | 0.74 | MAPT (0.55) | MAPTSMN1; SMN2LMNAL3MBTL1RAB9A | |
| SCHEMBL5042843 | 0.73 | CYP3A4 (0.51) | MAPTLMNARAB9AMAOBMEN1 | |
| SCHEMBL5033238 | 0.73 | MAPT (0.54) | MAPTLMNARAB9AMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432421-A1 | QUINOLINE DERIVATIVES AS NEUROPEPTIDE Y ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028726-A1 | QUINOLINE DERIVATIVES AS NEUROPEPTIDE Y ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | WO | disclosed |