Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873173 | 1.00 | MCHR1 (0.42) | MCHR1CDK7CDK9MAPK8AURKB | |
| SCHEMBL6876213 | 0.88 | GLA (0.48) | MCHR1CDK7CDK9MAPK14MEN1 | |
| SCHEMBL6876224 | 0.88 | GLA (0.48) | MCHR1CDK7CDK9MAPK14MEN1 | |
| SCHEMBL6874810 | 0.88 | MCHR1 (0.42) | MCHR1CDK7CDK9MAPK8MAPK14 | |
| SCHEMBL6874802 | 0.88 | MCHR1 (0.42) | MCHR1CDK7CDK9MAPK8MAPK14 | |
| SCHEMBL6872847 | 0.87 | EPHX2 (0.47) | MCHR1MAPK8AURKBMAPK14MEN1 | |
| SCHEMBL6872853 | 0.87 | EPHX2 (0.47) | MCHR1MAPK8AURKBMAPK14MEN1 | |
| SCHEMBL6878450 | 0.86 | MAPK8 (0.41) | MCHR1MAPK8AURKBMAPK14TRPV1 | |
| SCHEMBL6880649 | 0.86 | AURKB (0.41) | MCHR1MAPK8AURKBMAPK14KDR | |
| SCHEMBL6869275 | 0.86 | MAPK14 (0.54) | MCHR1MAPK8AURKBMAPK14HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |