Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874810 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6459601 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6459615 | 0.90 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6876325 | 0.88 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6876330 | 0.88 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873169 | 0.88 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873173 | 0.88 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875689 | 0.87 | MAPK14 (0.50) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875360 | 0.87 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6875353 | 0.87 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |