Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.57 |
| ▸ | HRH1 | P35367 | 6/20 | 0.57 |
| ▸ | HTR2B | P41595 | 6/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873245 | 1.00 | MCHR1 (0.57) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878288 | 0.89 | MCHR1 (0.71) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878285 | 0.89 | MCHR1 (0.71) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6461744 | 0.87 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6461733 | 0.87 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875281 | 0.85 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875276 | 0.85 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458198 | 0.83 | MCHR1 (0.81) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6458207 | 0.83 | MCHR1 (0.81) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| Hydrochloric Acid SCHEMBL6462069 | 0.82 | MCHR1 (0.79) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |