Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 14/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.44 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873378 | 1.00 | GAA (0.54) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6878850 | 0.85 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6878847 | 0.85 | MCHR1 (0.58) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6456005 | 0.85 | KLK7 (0.59) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6456016 | 0.85 | KLK7 (0.59) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6877485 | 0.84 | MCHR1 (0.52) | KMT2AMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6877476 | 0.84 | MCHR1 (0.52) | KMT2AMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6874303 | 0.84 | TSHR (0.46) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6874310 | 0.84 | TSHR (0.46) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6879228 | 0.83 | MCHR1 (0.46) | MCHR1MAPK8ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |